Tirzepatide is a novel treatment for type 2 diabetes and obesity. It's a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that has emerged as a potential breakthrough in combating both type 2 diabetes and obesity.
So what does that actually mean? Well the TL;DR is that Tirzepatide works by mimicking the effects of natural hormones that help regulate blood sugar levels. It enhances insulin secretion, slows gastric emptying, and reduces appetite.
Today we are digging into recent studies to help you understand the science behind Tirzepatide!
How Tirzepatide Helps Treat Type 2 Diabetes
Tirzepatide can offer certain benefits for those dealing with Type 2 diabetes, including improvements to blood sugar control, assistance in weight loss, and a lower risk of hypoglycemia compared to other diabetes medications.
In a 2022 study published by JAMA, researchers looked at the effect of subcutaneous Tirzepatide on glycemic control in patients with type 2 diabetes, when added to titrated insulin glargine.
Researchers found that adding once-weekly tirzepatide for patients with inadequate glycemic control despite treatment with insulin glargine caused significant improvements in glycemic control and weight reduction over 40 weeks compared to placebo.
Tirzepatide can be combined with other diabetes medication, though it's important to monitor blood sugar levels closely to avoid risk of hypoglycemia. As always it's important to consult your healthcare provider before starting any treatment.
How Tirzepatide Could Help You Lose Weight
According to several recent studies, Tirzepatide is a treatment that could help overweight people lose weight and keep it off with continued use. This is likely due to its effects on appetite and food intake.
A 2022 double-blind study published in the New England Journal of Medicine looked at the effects of once-weekly treatment on obese individuals. Researchers tested 5 mg, 10 mg, and 15 mg doses and found that they all provided significant and sustained reductions in body weight among overweight people.
Results showed an average weight reduction of 15.0% to 20%, with the treatment significantly outpacing the placebo! The study also reported improvements in cardiometabolic measures and physical function for those who used the peptide.
A randomized clinical trial published by JAMA just this year showed Tirzepatide can help those who lost weight with it also keep that weight off longer. While those who stopped treatment with Tirzepatide did report some regain in weight, those who continued with weekly treatments appeared not only to maintain their weight reduction, but in some cases they even lost more weight!
These results were corroborated by another clinical trial published just this year by JAMA, which found those who continued their Tirzepatide treatment maintained at least 80% of their weight loss during the study period, emphasizing its long-term efficacy.
Is it safe to use Tirzepatide to lose weight?
As with all treatments, we have to consider the safety of any treatment. Luckily, Tirzepatide has shown no major safety concerns. All three studies mentioned above revealed manageable gastrointestinal adverse events, indicating promising safety for tirzepatide in reducing body weight.
That said, those who have with a personal or genetic history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use Tirzepatide. And those who have severe gastrointestinal disease should also avoid this treatment. Consult with your healthcare professional before starting the use of Tirzepatide.
Summary
In conclusion, Tirzepatide represents a significant advancement in the realm of obesity management and treatment of type 2 diabetes. The findings from recent studies underscore its potential to help manage bloodsugar levels, facilitate initial weight loss and sustain these reductions over time. Consult with your healthcare provider about whether Tirzepatide is an option in your health journey.
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